Abstract
AbstractTo probe the utility of a multivalent approach for fucosidase inhibition, a series of di‐ and tri‐valent imino sugars based on L‐fuco‐configured 1,4‐imino‐ and 1,4‐bis(imino)‐cyclitol epitopes has been synthesized and analyzed for fucosidase inhibition with the best trivalent species yielding a modest improvement in binding constant. Structural analysis of a representative pair of mono‐ and tri‐valent imino sugars has been performed on a bacterial fucosidase, BtFuc2970. The 3D structures show binding of the imino‐cyclitol in the 3E conformation, consistent with the known pathway for fucosidase action.
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