Abstract
Solubility development of supramolecular host–guest interaction between Alverine citrate with α and β-cyclodextrins were studied throughout the article. 2:1 host to guest stoichiometry of the inclusion complexation in the solution phase were confirmed by the Job’s plot. The IR, DSC, SEM and PXRD data turn out to be supportive about the phenomenon, inclusion complexation. Association constants and thermodynamic parameters of the inclusion complexes were obtained using UV–vis and spectrofluorometric measurement. The mechanism of inclusion complexation was explored by 1H and 2D ROESY NMR spectroscopy. Binding ability of the drug molecule, Alverine citrate with the HSA and the controlled release of the drug molecule from inclusion complexes were studied at PH-7.4 by spectrofluorimetricaly. Studied phenomenon thus develops the solubility of merely soluble drug into water, consequently makes bioavailable and enriches the drug delivery system.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
