Abstract
ObjectiveTo study the clinical effect of body mass index (BMI) in the optimal time of weaning from sequential invasive-noninvasive mechanical ventilation (MV) by treating severity chronic obstructive pulmonary disease (COPD) patients.Methods94 patients with severity COPD were divided into the control group (BMI<21) and the study group (BMI>21). These two groups were treated by similar symptomatic therapies such as mechanical ventilation, antibacterial, antispasmodic, relieving asthma, antitussive, expectorant, correction of electrolyte imbalance and acid-base balance disorders, strengthen nutritional support, etc.ResultsCompared with the control group, the study group had shorter duration of invasive mechanical ventilation, non-invasive mechanical ventilation time, total mechanical ventilation time, total hospital stay (P<0.01). There are significant differences between these two groups in re-intubation rate, VAP occurred in the number of case, hospital mortality rate in 28 days (P<0.05).ConclusionsIt is difficult to wean successfully from sequential mechanical ventilation for severity COPD patients (BMI<21), so BMI as one of important reference index can be used to estimate the optimal time for weaning from sequential mechanical ventilation for severity COPD patients.
Highlights
Compared with the control group, the study group had shorter duration of invasive mechanical ventilation, non-invasive mechanical ventilation time, total mechanical ventilation time, total hospital stay (P
The traditional invasive mechanical ventilation is used to treat severity COPD patients combined with more secretion, and transfer from invasive to non invasive mechanical ventilation at the time of pulmonary infection control window (PIC Window) appeared [1], we had become consensus on invasive-noninvasive mechanical ventilation technique in treatment of chronic obstructive pulmonary disease at acute exacerbation phase (AECOPD)
There are no objective indicators to measure when weaning from invasivenoninvasive mechanical ventilation
Summary
94 patients with severity COPD were divided into the control group (BMI21) These two groups were treated by similar symptomatic therapies such as mechanical ventilation, antibacterial, antispasmodic, relieving asthma, antitussive, expectorant, correction of electrolyte imbalance and acidbase balance disorders, strengthen nutritional support, etc. There is no significant difference between these two groups in age, gender, course of diseases, type of COPD, the score of APACHE II, result of blood gas analysis (P>0.05) Treatment These two groups were treated by similar symptomatic therapies such as antibacterial, antispasmodic, relieving asthma, antitussive, expectorant, correction of electrolyte imbalance and acid-base balance disorders, strengthen nutritional support, etc. The treatment of the study group was the same as that of the control group until BMI >21, weaning from mechanical ventilation
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