Abstract
Psidium guajava L. is widely used like food and in folk medicine all around the world. Many studies have demonstrated that guava leaves have anti-hyperglycemic and anti-hyperlipidemic activities, among others, and that these activities belong mainly to phenolic compounds, although it is known that phenolic composition in guava tree varies throughout seasonal changes. Andalusia is one of the regions in Europe where guava is grown, thus, the aim of this work was to study the phenolic compounds present in Andalusian guava leaves at different oxidation states (low, medium, and high). The phenolic compounds in guava leaves were determined by HPLC-DAD-ESI-QTOF-MS. The results obtained by chromatographic analysis reported that guava leaves with low degree of oxidation had a higher content of flavonols, gallic, and ellagic derivatives compared to the other two guava leaf samples. Contrary, high oxidation state guava leaves reported the highest content of cyanidin-glucoside that was 2.6 and 15 times higher than guava leaves with medium and low oxidation state, respectively. The QTOF platform permitted the determination of several phenolic compounds with anti-diabetic properties and provided new information about guava leaf phenolic composition that could be useful for nutraceutical production.
Highlights
Psidium guajava (P. guajava) L., from the Myrtaceae family, is common throughout tropical and subtropical areas [1] and Andalusia is one of the regions in Europe where guava is grown
The aim of this work was to study the phenolic compounds present in Andalusian guava leaves at different oxidation states by HPLC-diode array detector (DAD)-ESI-QTOF-MS
Due to the UV and MS spectrum and by co-elution with a commercial standard, this component has been identified as cyanidin-3-O-glucoside
Summary
Psidium guajava (P. guajava) L., from the Myrtaceae family, is common throughout tropical and subtropical areas [1] and Andalusia is one of the regions in Europe where guava is grown. It is widely used like food and in folk medicine all around the world. The response of the different classes of phenolic compounds, especially flavonoids, vary substantially [9] This fact plays an important role in finding the best conditions of the leaf in order to obtain the best recovery of the target compounds for the development of a promising alternative source for ameliorating diabetes complications [2,3,4]
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