Abstract
Aim:To examine the prognostic value of the platelet-to-lymphocyte ratio (PLR) in the adjuvant renal cell carcinoma setting.Materials & methods:Patients received adjuvant sunitinib (50 mg/day; 4 weeks on/2 weeks off) or placebo. The primary end point was disease-free survival (DFS).Results:In 609 patients, DFS was similar for baseline PLR <140 versus ≥140 overall (median: 6.4 vs 5.9 years; hazard ratio: 0.9; 95% CI: 0.7–1.2). A ≥25% decrease in PLR at week 4 overall was associated with longer DFS versus no change (hazard ratio: 0.8; 95% CI: 0.6–1.0).Conclusion:Baseline PLR was not prognostic for DFS with adjuvant sunitinib treatment in patients with renal cell carcinoma.Clinical Trials Registration: NCT00375674 (ClinicalTrials.gov)
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