Abstract
The paper is proposed to explore the potential effects of Shufeng Jiedu Capsule against COVID-19. The ingredients and targets of Shufeng Jiedu Capsule were collected by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the gene names of potential targets were extracted by UniProtKB. Then we did protein-protein interaction networks functional enrichment analysis by the STRING platform, reconstructed drug-target pathways and networks to predict the likely protein targets of the capsule against COVID-19 with software Cytoscape 3.6.1, and carried out GO enrichment analysis and KEGG analysis with R 5.3.2 software. At last we validated our predictions on molecular docking. The results suggested that Shufeng Jiedu Capsule contained 155 ingredients and 237 targets, including 26 main active ingredients and 45 key targets. There were 2334 biological processes (BP), 103 cell composition (CC) and 198 molecular functions (MF) in GO Enrichment Analysis, and 177 pathways in the KEGG analysis. The molecular docking analysis showed that binding energy for 26 main active ingredients ranged from -32.21 to -25.94 kJ·mol-1, and the main targets bind to SARS-CoV-2 3CL hydrolase by acting on CASP9, PRKCA, RELA and others. Our study suggested that Shufeng Jiedu Capsule has potential therapeutic effects on COVID-19.
Highlights
Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus and is highly infectious
The ingredients and targets of Shufeng Jiedu Capsule were collected by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the gene names of potential targets were extracted by UniProtKB
The results suggested that Shufeng Jiedu Capsule contained 155 ingredients and 237 targets, including 26 main active ingredients and 45 key targets
Summary
Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus and is highly infectious It was named by the World Health Organization on January 12, 2020, and its pathogen was named SARS-CoV-2 [1]. Chinese medicine therapy is recommended from the third edition of “Novel Coronavirus Pneumonia Diagnosis and Treatment Scheme” issued by National Health Commission of the People’s Republic of Chian and National Administration of Traditional Chinese Medicine, and achieved good results in treatment [4] [5] [6] [7]. Shufeng Jiedu Capsule was recommended from the sixth edition of “Novel Coronavirus Pneumonia Diagnosis and Treatment Scheme”; the formula was from “Qudu San”, which is made from Polygoni Cuspidati Rhizoma Et Radix (Huzhang), Forsythiae Fructus (Lianqiao), Isatidis Radix (Banlangen), Radix Bupleuri (Chaihu), Herba Patriniae (Baijiangcao), Verbenae Herb (Mabiancao), Phragmitis Rhizoma (Lugen), and licorice (Gancao). We selected relevant targets and pathological mechanisms of Shufeng Jiedu Capsule for the treatment of COVID-19 by network pharmacology and molecular docking [12], and provided the basis for further study
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
