Exploration of the application of gene editing technology in the treatment of colorectal cancer, taking CRISPR technology as an example for editing FAT4 genes

Abstract

Colorectal cancer, the fourth most common cancer in the world, is the most common digestive tract tumor. At present, conservative treatment is still the main treatment method for colorectal cancer in clinical practice. Among the pathogenic factors of colorectal cancer, genetic factors need to be emphasized. Currently, many studies have focused on pathological studies of related gene mutations, mostly focusing on genes such as p53 and APC, and their molecular biological reactions have been thoroughly studied. However, research on other pathogenic genes is still lacking, and there is limited research on specific treatment methods. With the birth of CRISPR-Cas9 technology, applying of gene editing technology in the field of cancer has made breakthrough progress. This article will consider combining gene editing technology with related gene mutations in colorectal cancer, attempting to explore the possibility of applying gene editing technology in the field of cancer treatment, proposing feasibility for new treatment plans for colorectal cancer, and also providing new treatment ideas for future cancer treatment research.