Abstract

Quinoline is one of the most important simple nitrogen heterocycles, being widespread in nature and present in a broad variety of pharmacologically active compounds. Specifically, quinoline is renowned antimalarial agents from several past decades and showed strong potential in this field. 3‐Formyl‐quinoline is a versatile precursor which transformed through the several easy methods into a wide range of biologically valuable scaffolds. The exploration of 3‐formyl‐quinoline gained much more attention to medicinal chemists in the field of drug discovery to design and synthesize new fused/tethered quinolines as potent therapeutical agents. The aim of this review, which covers the period from 2011 to 2023, is to update the role of formyl functionality of quinolines showing the extraordinary ability to play role in organic synthesis.

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