Abstract
Department of Chemistry, Korea University, Seoul 136-701, KoreaReceived July 8, 2011, Accepted August 23, 2011Key Words : Combinatorial chemistry, Chemical library, Ureidobenzothiazole, Neuroinflammation, InhibitorCombinatorial chemistry serves as a powerful tool in leaddiscovery and lead optimization by facilitating the rapidgeneration of potential candidates for screening. Leadoptimization involves structural modifications of a hitcompound to a lead compound that has demonstrated thedesired biological or pharmacological activities, often in anin-vitro assay system. Among the broad range of templates,heterocyclic scaffolds represent the most promising mole-cules as leading structures for the discovery of novel syn-thetic drugs. In particular, the 2-aminothiazole core is foundin numerous drugs and clinical and preclinical candidatesthat address a broad spectrum of targets.
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