Abstract
Exploration of Molecular Network Variations in Different Subtypes of Human Non-functional Pituitary Adenomas.
Highlights
Reviewed by: Luiz Augusto Casulari, University of Brasilia, Brazil Renan Magalhaes Montenegro, Universidade Federal do Ceará, Brazil
High-degree heterogeneity occurs in NFPAs, which is present as different subtypes of cell origins and hormones expressed in a tumor tissue; for example, intact gonadotroph with luteinizing hormone (LH)/follicle-stimulating hormone (FSH)-positive (40–79%), null cell without hormone expression (17%), oncocytoma without hormone expression (6%), silent corticotroph with adrenocorticotropic hormone (ACTH)-positive (8%), and silent somatotroph with growth hormone (GH)-positive (3%)
In our studies on NFPA, two-dimensional gel electrophoresis (2DGE)-based quantitative proteomics, post-translational modifications (PTMs)-proteomics, bioinformatics, and pathway network-based systems biology were used to investigate the variations in proteome and protein molecular networks of an NFPA [1, 6, 14, 16, 20]. (i) For NFPAs compared to pituitary controls [6, 16, 20], a set of 50 differentially expressed proteins (DEPs), 9 nitroproteins, and 3 nitroprotein–protein complexes were identified [6, 16]
Summary
Reviewed by: Luiz Augusto Casulari, University of Brasilia, Brazil Renan Magalhaes Montenegro, Universidade Federal do Ceará, Brazil. The documented omics data demonstrate obvious variations in transcriptome and proteome between NFPAs and controls [6], between invasive and non-invasive NFPAs [13, 14], and among four hormone-expressed NFPA subtypes [1].
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