Exploration of intermolecular interactions of the anti-tuberculosis drug, isoniazid with the citrate salt solutions using viscometric, acoustic, and spectroscopic techniques

Abstract

Various molecular interactions, physicochemical, and solution properties are studied in terms of their viscometric, thermo-acoustic, and spectroscopic properties at T = (298.15–318.15)K and 0.1 MPa atmospheric pressure for isoniazid (INH) in the pure water and in INH + water + K3Cit/Na3Cit systems respectively. Ultrasonic velocity (u) and, viscosity (η) were measured at the experimental temperatures. Falkenhagen coefficients, A, and Jones-Dole coefficients, B, have been calculated from experimental viscosity data. These two viscometric parameters and the viscosity transfer B-coefficient, ΔtrB ofisoniazid (INH) have been used to observe molecular interaction in the studied solutions. The ultrasonic velocity data was extensively used to calculate the acoustical parameters like apparent molar compressibility, Kϕ,S, limiting apparent molar compressibility ,Kϕ,S0 and transfer compressibility ,ΔtrKs,ϕ0 of the solutions. The presence of H-bonding and other interactions among the solutions have been observed from the FTIR spectroscopy. The results obtained by these methods have been used to look over the nature of, solvent–solvent, drug-drug, and drug-solvent interactions and also the structure promoting/breaking nature of INH in the pure water and in INH + water + K3Cit/Na3Cit systems respectively.