Abstract
The composition of the culture medium has great influence on the metabolite production of the marine fungus Pseudallescheria boydii F44-1. By adding amino acids to GPY culture medium, two new bisindole alkaloids, pseudboindoles A and B (1 and 2), together with 11 known indole alkaloids were isolated from the culture broth. Their structures were elucidated by comprehensive analysis of the NMR, MS, IR, and UV spectra. The 3,3′-cyclohexylidenebis(1H-indole) (3) showed cytotoxic activity against various cancer cell lines.
Highlights
Marine indole alkaloids are an increasingly growing class of secondary metabolites
The result proves again that an amino acid-directed strategy is effective for inducing the marine fungi to produce diverse alkaloids
After revealing these relationships, the application of this strategy will be more efficient
Summary
2015, about 800 new marine indole alkaloids were obtained [1]. The natural occurrence of indole alkaloids is the result of biosynthesis via the coupling of the inessential amino acid tryptophan with other amino acids and structural fragments. Based on this consideration, our research group established an amino acid-directed strategy to explore the potential of marine fungi to produce diverse alkaloids. More than forty novel and/or bioactive indole alkaloids have been obtained from marine fungi. When cultured in glucose–peptone–yeast (GPY) extract medium supplemented with L-tryptophan, L-phenylalanine, L-threonine, and D,L-methionine, the marine fungus Scedosporium apiospermum F41-1 produced 12 new indole alkaloids.
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