Abstract
Objective: The aim of the present study was to investigate the in vivo antioxidant potential of 50% ethanolic extract of Sesamum indicum against high-fat diet-induced rats.
 Methods: Animals were treated with plant extract for 30 d, and a high-fat diet was given to all groups except plain control, throughout, out the study. And alpha-tocopherol acetate (Vit, E) was used as standard. Pre-treatment with 16 mg/100 gm of body weight of 50% ethanolic extract of Sesamum indicum improved the Superoxide dismutase, catalase, glutathione, and lipid peroxidation levels significantly as compared to control group.
 Results: The present studies revealed that Sesamum indicum has significant in vivo antioxidant activity and can be used to protect tissue from oxidative stress. The result showed that the activities of SOD, catalase, lipid peroxidase, and glutathione, in the group treated with high-fat diet declined significantly than that of normal group.
 Conclusion: 50% ethanolic extract of in the dose of Sesamum indicum 16 mg/100 gm of body weight, has improved the SOD, catalase, glutathione, and lipid peroxidase levels significantly, which were comparable with high-fat-diet-induced rats. Based on this study we conclude that the 50% ethanolic extract of Sesamum indicum possesses in vivo antioxidant activity and can be employed in protecting tissue from oxidative stress.
Highlights
The use of plants in the management and treatment of diseases started with the advent of life
In phytochemicals investigation it was found that different extract of Kunjad (Sesamum indicum) contained alkaloids, phenol, carbohydrate, protein, sterols, glycosides, While in safety study it was found that heavy metals (Arsenic, Mercury, Cadmium) were not found to be present, only Lead are present, and microbial load count (Bacterial count 600 and yeast and mould 50) were found which is within permissible limit as per WHO guidelines, while aflatoxins, pesticides and specific pathogen was found to be absent in the crude drug sample, indicating that the drug is free from toxicity
The results showed that the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GR) in the liver, brain and serum of control and experimental groups of rats was significantly lower in the high fat diet control group as compared to the plain control group
Summary
The use of plants in the management and treatment of diseases started with the advent of life. The oil from sesame plant is an important ingredient in Unani remedies in India and is used in Chinese medicine to increase energy and prevent aging due to the presence of bioactive components present in the seed including polyunsaturated fatty acids, phytosterols, tocopherols, vital minerals and unique class of phenylpropanoid compounds namely lignans such as sesamin, sesamol and sesamolin. The oil from sesame plant is an important ingredient in Unani remedies in India and is used in Chinese medicine to increase energy and prevent aging due to the presence of bioactive components present in the seed including polyunsaturated fatty acids, phytosterols, tocopherols, vital minerals and unique class of phenylpropanoid compounds namely lignans such as sesamin, sesamol and sesamolin9 These phytochemicals provide defense mechanism against reactive oxygen species and increases keeping quality of oil by preventing oxidative rancidity [10, 11]. Keeping in view of all these facts, the present study is being carried out with the following various parameters
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