Abstract
Background and Aims : Micro-RNA (miRNA) act as negative post-transcriptional regulators of gene expression and are involved in every stage of atherosclerotic plaque development. Statins remain the most common therapeutic agent for lipid lowering, and there is great interest in understanding the pleiotropic effects of statins as well as investigating drug combination therapies alongside statins. Here we investigated a dual statin/miRNA combination therapy approach to target human aortic SMC (HAoSMC) activation.
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