Abstract
DNA nucleobase sensors provide crucial information for diagnosing diseases, analyzing genetics, and advancing biological research by detecting and identifying DNA sequences in real-time. This research examined how GeTe monolayer interact with DNA nucleobases through adsorption. The adsorption strengths of the four bases on the adsorbent surface followed the order of G > C > T > A. Analysis of electronic properties indicated that the interaction between nucleobases and GeTe primarily involves physical adsorption. Additionally, higher adsorption energies led to greater rearrangement of surface electrons and changes in the adsorbent's potential barrier, resulting in significant variations in the work function (WF) value. The desorption times at 498K were A (0.02 h), G (15.8 h), C (0.72 h), and T (0.43 h), indicating the potential of GeTe as a reusable material for nucleobase sensors. We can amplify the adsorption strength (30 %–45 %) and improve the discrimination between nucleobases (208 %–808 %) by employing solvents possessing higher dielectric constants. Comparisons with recent research validated the superior adsorption performance and selectivity of the material used in this study, highlighting the promising application of the GeTe monolayer in nucleobase sequencing technology.
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