Abstract
The objective of the present work was to formulate the enteric minitablets of isoniazid by cold extrusion method. The minitablets were prepared using isoniazid, hydroxylpropylmethylcellulose phthalate and dibasic calcium phosphate. The minitablets were coated using hydroxypropylmethylcellulose phthalate. Full factorial design was adopted to optimize the formulation. The minitablets showed good flow and acceptable friability. The drug release was resisted in 0.1 N HCl for 2 h from the optimized batch. The optimized batch showed more than 90% of drug release in phosphate buffer in 15 min. Capsules containing rifampicin powder and enteric isoniazid minitablets showed complete drug release in acidic and alkaline media respectively. The process of cold extrusion appears to be an attractive alternative to by-pass the existing patents.
Highlights
Research PaperExploration of Cold Extrusion for the Preparation of Enteric Minitablets of Isoniazid
The objective of the present work was to formulate the enteric minitablets of isoniazid by cold extrusion method
Preparation of isoniazid minitablets: Isoniazid, hydroxypropylmethylcellulose phthalate and dibasic calcium phosphate were mixed for 10 min
Summary
Exploration of Cold Extrusion for the Preparation of Enteric Minitablets of Isoniazid. The objective of the present work was to formulate the enteric minitablets of isoniazid by cold extrusion method. The minitablets were prepared using isoniazid, hydroxylpropylmethylcellulose phthalate and dibasic calcium phosphate. The drug release was resisted in 0.1 N HCl for 2 h from the optimized batch. The optimized batch showed more than 90% of drug release in phosphate buffer in 15 min. Capsules containing rifampicin powder and enteric isoniazid minitablets showed complete drug release in acidic and alkaline media respectively. The enteric dosage forms are usually developed to overcome problems such as gastric irritation, drug stability in gastrointestinal tract, poor absorption or permeability and incompatibility with other drugs 1. Shishoo and co-workers reported the incompatibility of rifampicin and isoniazid in acidic dissolution medium 4. The investigators further reported that isoniazid is poorly absorbed from stomach, but it is well absorbed from all
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