Abstract
In this study, we investigated blood lipoprotein and lipid fraction profiles, quantified using nuclear magnetic resonance, in a cohort of 844 healthy blood donors, integrating standard univariate and multivariate analysis with predictive modeling and network analysis. We observed a strong association of lipoprotein and lipid main fraction profiles with sex and age. Our results suggest an age-dependent remodulation of lipase lipoprotein activity in men and a change in the mechanisms controlling the ratio between esterified and non-esterified cholesterol in both men and women.
Highlights
In this study, we investigated blood lipoprotein and lipid fraction profiles, quantified using nuclear magnetic resonance, in a cohort of 844 healthy blood donors, integrating standard univariate and multivariate analysis with predictive modeling and network analysis
Lipids are transported in the blood by proteins; lipoproteins exist in different densities: chylomicrons, very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), intermediate-density lipoprotein (IDL), and high-density lipoprotein (HDL)
Many more sex- and age- lipoprotein associations are being discovered [5,14,15,16]: in age group theInera of precision medicine, understanding how sex and differences age shape theinlipidome can lead this study, we investigate sex- and age-specific the plasma lipidome to better diagnosis and treatment of conditions that occur more frequently in one of the of 844 young and middle-aged healthy blood donors of both sexes who were analyzed for two sexes, present sex-specific symptoms and outcomes, or are characteristic of a specific their lipoprotein blood profiles via nuclear magnetic resonance (NMR) spectroscopy age group [17]
Summary
We investigated blood lipoprotein and lipid fraction profiles, quantified using nuclear magnetic resonance, in a cohort of 844 healthy blood donors, integrating standard univariate and multivariate analysis with predictive modeling and network analysis. Lipids are the most abundant biological molecules in human plasma [1] This group of small molecular weight molecules shows large structural and functional variations: they are fundamental building blocks of the cell wall and are key components of the cell membrane and other cellular compartments, including the nuclear membrane, the endoplasmic reticulum, and the Golgi apparatus, as well as trafficking vesicles such as endosomes and lysosomes [2]. Lipids are transported in the blood by proteins; lipoproteins exist in different densities: chylomicrons, very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), intermediate-density lipoprotein (IDL), and high-density lipoprotein (HDL). These lipoproteins determine where the lipid is transported to, which contributes to the wide functional variability of the lipidome. Alterations of lipoprotein profiles have been associated with different types of cancer [6,7,8] and autoimmune diseases [9,10,11]
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