Exploration of bioactivity in traditionally used medicinal plants

Abstract

Arachidonic acid (AA) is metabolized in the body through two main metabolic pathways with the enzymes: cyclooxygenases (COX) and lipoxygenases (LOX). Elevated levels of prostanoids and leukotrienes, products of the two respective pathways, have been linked to inflammatory diseases as well as to early stages of carcinogenesis. Finding a dual inhibitor of COX and LOX is promising in preventing the inflammation and diseases that are linked to the overproduction of both pathways while minimizing the side effects associated with inhibition of individual pathways.