Abstract
With expansion of our understanding of pathogen effector strategies and the multiplicity of their host targets, it is becoming evident that novel approaches to engineering broad-spectrum resistance need to be deployed. The increasing availability of high temporal gene expression data of a range of plant–microbe interactions enables the judicious choices of promoters to fine-tune timing and magnitude of expression under specified stress conditions. We can therefore contemplate engineering a range of transgenic lines designed to interfere with pathogen virulence strategies that target plant hormone signalling or deploy specific disease resistance genes. An advantage of such an approach is that hormonal signalling is generic so if this strategy is effective, it can be easily implemented in a range of crop species. Additionally, multiple re-wired lines can be crossed to develop more effective responses to pathogens.
Highlights
Recent efforts in sequencing of pathogen genomes have revealed numerous new insights into the processes employed by plant pathogens
One of such insights was the identification of surprisingly large numbers of candidate effector proteins encoded by pathogen genomes
We briefly examine opportunities and challenges in genetic-based disease intervention strategies and discuss the possibility of solutions that precisely target a universal pathogen virulence strategy, i.e. modulation of plant hormone signalling networks
Summary
With expansion of our understanding of pathogen effector strategies and the multiplicity of their host targets, it is becoming evident that novel approaches to engineering broad-spectrum resistance need to be deployed. We can contemplate engineering a range of transgenic lines designed to interfere with pathogen virulence strategies that target plant hormone signalling or deploy specific disease resistance genes. An advantage of such an approach is that hormonal signalling is generic so if this strategy is effective, it can be implemented in a range of crop species. Multiple re-wired lines can be crossed to develop more effective responses to pathogens
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