Abstract
Correlated substitution patterns between residues of a protein family have been exploited to reveal information on the structures of proteins. However, such studies require a large number (e.g., the order of one thousand) of homologous yet variable protein sequences. So far, most studies have been limited to a few exemplary proteins for which a large number of such sequences happen to be available. Rapid advances in genome sequencing will soon be able to generate this many sequences for the majority of common bacterial proteins. Sequencing a large number of simple eukaryote such as yeast can in principle generate similar number of common eukaryotic protein sequences, beyond a collection of highly amplified protein domains which already reach the necessary numbers.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
