Exploitation of metal-organic framework/ polyaniline composite as an efficient transducer for potentiometric determination of epinastine hydrochloride

Abstract

Due to their unique characteristics, such as varying pore diameters, crystalline organized structures, huge surface areas, and chemical tunability, metal-organic frameworks are now thought to be particularly potential modifiers in electrochemical analysis. In this study, polyaniline was successfully polymerized around the metal-organic framework NH2-MIL-53(Fe) to create a conductive transducer composite that was applied to design a potentiometric carbon paste electrode for the reliable detection of Epinastine hydrochloride (EP.HCl). FT-IR, XRD patterns, and TEM data support the creation of the synthesised NH2-MIL-53(Fe)/PANI composite and prove that PANI coated the surface of NH2-MIL-53(Fe). In optimal circumstances, the electrode has been efficiently used for monitoring EP.HCl in its pure form, ophthalmic preparation, and artificial aqueous humor. At a limit of detection of 7.5 × 10−8 mol L−1, the response signal of the CPE rose linearly in the concentration between 1 × 10−7 to 1 × 10−2 mol L−1. With no surface renewal for 15 weeks, the suggested sensor is marked by significant stability and selectivity.