Exploitation of Cell Mediated Immune Responses to Cancer Immunotherapy

Tilaye Atnaf Ashine

doi:10.7176/jmpb/59-03

Abstract

Individual human tumors arise through a combination of genetic and epigenetic changes that facilitate immortality. Cancer occurs when there are changes to genes that control the way our cells grow and divide.. The increase in the prevalence of cancer with lack of specific treatment options became public health problem particularly in middle and low income nations. Activation of the immune system by products of viral oncogene prevents viral induced cancers. The in vitro stimulation of Dendritic cells with tumor or tumor antigen in the presence of cytokines for cross activation of CD8+ and CD4+ T cells or restoration of T cells functions by blockade of immune blockers or modification tumor microenvironment or adoptive transfer of immune cells and stem T cells are promising cancer therapies. Compared with the convectional cancer therapies, immunotherapies are most tumors targeted without harmful side effects. DOI : 10.7176/JMPB/59-03 Publication date :September 30 th 2019

Highlights

Exploitation of Cell Mediated Immune Responses to Cancer ImmunotherapyTILAYE ATNAF ASHINE1 TESFAYE SISAY TESEMA2 1.College of Natural and Computational Science Department of Biology (Stream of Medical Biotechnology), Madda Walabu University, PO box 47, Bale Robe, Ethiopia 2.Unit of Health Biotechnology, Director, Institute of Biotechnology, Addis Ababa University
Cancer is a cell that has lost its normal growth control mechanism
Tumor regression following administration of genetically engineered T cells has been observed in B-cell malignancies, melanoma, and synovial sarcoma (Couzin-Frankel, 2013; Farkona et al, 2016; Lacombe, 2016; Schumacher & Schreiber, 2015)

Summary

Exploitation of Cell Mediated Immune Responses to Cancer Immunotherapy

TILAYE ATNAF ASHINE1 TESFAYE SISAY TESEMA2 1.College of Natural and Computational Science Department of Biology (Stream of Medical Biotechnology), Madda Walabu University, PO box 47, Bale Robe, Ethiopia 2.Unit of Health Biotechnology, Director, Institute of Biotechnology, Addis Ababa University

Introduction

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Conclusion