Abstract
Aim: The purpose of this study was to design a metformin nanoparticles (NPs)-loaded buccoadhesive film for enhanced drug bioavailability. Materials & methods: The NPs were prepared and incorporated into a hydroxypropyl methylcellulose-chitosan blend film. Three levels of a three-factor, Box-Behnken design were used to evaluate the critical formulation variables. The drug permeation was also examined using sheep buccal mucosa. Results & conclusion: The results verified the formation of spherical NPs with an average size of 177.8±6.42nm and entrapment efficiency of 78.03±0.23%. The optimum conditions for nanofilms were predicted to be: hydroxypropyl methylcellulose (700mg), glycerol (50mg) and chitosan (0.15 %w/v). The nanofilm showed a high drug permeation within 6h. The metformin nanofilm offers an excellent opportunity for buccal drug delivery.
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