Abstract
Chemotherapy-induced nausea and vomiting (CINV) is one of the most common and feared side effects in cancer patients undergoing chemotherapy. Scientific evidence proves its detrimental impact on a patient's quality of life (QoL), treatment compliance, and overall healthcare cost. Despite the CINV-management landscape witnessing a radical shift with the introduction of novel, receptor-targeting antiemetic agents, this side effect remains a chink in the armor of a treating oncologist. Though global guidelines acknowledge patient-specific risk factors and chemotherapeutic agent emetogenic potential in CINV control, a “one-fit-for-all” approach cannot be followed across all geographies. Hence, in a pioneering attempt, India-based oncologists conveyed easily implementable, region-specific, consensus-based statements on CINV prevention and management. These statements resulted from integrating the analysis of scientific evidence and guidelines on CINV by the experts, with their clinical experience. The statements will strengthen decision-making abilities of Indian oncologists/clinicians and help in achieving consistency in CINV prevention and management in the country. Furthermore, this document shall lay the foundation for developing robust Indian guidelines for CINV prevention and control.
Highlights
Chemotherapeutic approach for cancer is associated with the management of various adverse effects, which poses a great challenge to healthcare providers, having a detrimental impact on a patient’s overall quality of life (QoL) [1, 2]
The current antiemetic agents exert their action by targeting various receptors [5-hydroxytryptamine (5-HT3), neurokinin 1 (NK1), dopamine, etc.] involved in the emesis mechanism [18]
The result from the analysis revealed underreporting of the toxicities by the physicians [68]
Summary
Chemotherapeutic approach for cancer is associated with the management of various adverse effects, which poses a great challenge to healthcare providers, having a detrimental impact on a patient’s overall QoL [1, 2]. Uncontrolled/poorly controlled and prolonged CINV leads to malnutrition, dehydration, and electrolyte imbalance. These adverse effects further lead to complications such as esophageal tears and declining behavior (toward the treatment) [8]. Chemotherapy-Induced Nausea and Vomiting caused by CINV further transcends by negatively affecting a patient’s ability to carry out normal daily activities/chores [9]. Chemotherapy-induced nausea and vomiting has the propensity to increase morbidity, and healthcare cost, and interferes with the chemotherapy adherence and patient’s QoL [9,10,11,12,13,14,15,16,17]. The current antiemetic agents exert their action by targeting various receptors [5-hydroxytryptamine (5-HT3), neurokinin 1 (NK1), dopamine, etc.] involved in the emesis mechanism [18]
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