Abstract
Studies in animal models of epilepsy and pre-surgical patients have unanimously found a strong correlation between high-frequency oscillations (HFOs, > 80 Hz) and the epileptogenic zone, suggesting that HFOs can be a potential biomarker of epileptogenicity and epileptogenesis. This consensus includes the definition and standard detection techniques of HFOs, the localizing value of pathological HFOs for epileptic foci, and different ways to distinguish physiological from epileptic HFOs. The latest clinical applications of HFOs in epilepsy and the related findings are also discussed. HFOs will advance our understanding of the pathophysiology of epilepsy.
Highlights
High-frequency oscillations (HFOs) have become a new biomarker of epileptogenic zone in the brain
To record HFOs, bipolar montages are recommended as they can neutralize the artifacts carried by two adjacent electrodes [21]
HFOs are a reliable marker of pathological network activity, and should be adopted in the clinical practice to launch more targeted therapeutic methods
Summary
High-frequency oscillations (HFOs) have become a new biomarker of epileptogenic zone in the brain. Definition of HFOs HFOs are oscillatory high-frequency (> 80 Hz) brain signals recorded by electroencephalography (EEG) due to the transient local-field potential (LFP) oscillations.
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