Abstract
Calculated therapeutic doses of digitalis did not produce a significant change in the coronary blood flow of the dog. This confirms the results of Essex, Herrick, Baldes, and Mann. 28 Calculated toxic doses of digitalis decreased the coronary blood flow of dogs four to six hours after the drug had been administered. The diminution of flow persisted for several days after a single toxic dose of the drug. No myocardial lesions were observed after a therapeutic dose of digitalis, nor were they observed in one animal which received a toxic dose of digitalis. In the latter animal the coronary blood flow returned to the preinjection level within two days. Myocardial lesions were observed in one animal in which the coronary blood flow was kept well below the control level for twelve days by repeated injections of digitalis (toxic range). The diminution of coronary blood flow after the injection of toxic doses of digitalis could not be correlated consistently with changes in the pulse rate or systemic blood pressure. After the injection of toxic doses of digitalis the coronary blood flow returned to the control level in several experiments, and the animals recovered completely.
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