Abstract
In an extraordinary display of nature's myriad intricacies, in higher mammals the gonadotropin-releasing hormone (GnRH) pulse generator, which drives the pulsatile secretion of gonadotropin and sex steroids, is kept in abeyance until the onset of puberty, when it is reactivated with remarkable predictability during the pubertal transition. Its role in this transition is to promote sexual maturation in synchrony with somatic growth and maturation of sexual and social behaviors. In an earlier era, when most humans died before their 25th birthday, food availability was precarious, and environmental conditions were unpredictable, failure of the reproductive axis to activate in a timely . . .
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