Abstract
Lesions are described in the central nervous system of 35 germ-free and 6 conventional piglets after experimental infection with different strains of Erysipelothrix insidiosa, type B. As controls 12 piglets were evaluated. The predominant findings were disturbance of permeability in the form of plasmadiapedesis and erythrodiapedesis, degeneration of neurons, and swelling of endothelial cells. Malactic foci were found in the brain stem, cerebrum and the grey matter of the cervical spinal cord of piglets belonging to three different groups. The lumens of vessels often contained free bacteria and activated monocytes with phagocytosed Erysipelas bacteria. The virulence of the strains of Erysipelas for gnotobiotic piglets was very different. Only Erysipelas strain T 28, type B, caused severe lesions in the central nervous system.
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