Abstract

The intradermal as well as intraperitoneal injection of zirconium salts in CBA/J mice produced local foreign body type granulomas which regularly persisted for over eight months. None of the animals exhibited evidence of the late delayed immune type of epithelioid cell granulomatous hypersensitivity such as has been induced experimentally in man. Benign chondromas developed locally in the ear cartilage plate in half of the mice who had received zirconium injections in this area.

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