Abstract
The invasive potential of environmental and clinical strains of O1 and non-O1 Vibrio cholerae was examined. Mice injected subcutaneously (s.c.) with strains of these organisms were monitored for the development of lesions or mortality. Of 12 strains of non-O1 V. cholerae tested, 7 gave a high mortality rate. All other strains produced swelling and lesions at the site of inoculation. The injection of highly virulent strains of non-O1 V. cholerae produced bacteremia. In contrast, only 1 of the 10 strains of O1 V. cholerae tested was highly lethal, and bacteremia was not detected. The highly virulent strains of O1 and non-O1 V. cholerae failed to produce keratoconjunctivitis in the Sereny test. A qualitative enzyme study showed no differences in ability to produce enzymes associated with invasiveness.
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