Experimental validation of dual PPG local pulse wave velocity probe

Abstract

A novel dual photoplethysmograph (PPG) probe and measurement system for local pulse wave velocity (PWV) is proposed and demonstrated. The developed probe design employs reflectance PPG transducers for non-invasive detection of blood pulse propagation waveforms from two adjacent measurement points (28 mm apart). Transit time delay between the continuously acquired dual pulse waveform was used for beat-to-beat local PWV measurement. An in-vivo experimental validation study was conducted on 10 healthy volunteers (8 male and 2 female, 21 to 33 years of age) to validate the PPG probe design and developed local PWV measurement system. The proposed system was able to measure carotid local PWV from multiple subjects. Beat-to-beat variation of baseline carotid PWV was less than 7.5% for 7 out of 10 subjects, a maximum beat-to-beat variation of 16% was observed during the study. Variation in beat-to-beat carotid local PWV and brachial blood pressure (BP) values during post-exercise recovery period was also examined. A statistically significant correlation between intra-subject local PWV variation and brachial BP parameters was observed (r > 0.85, p < 0.001). The results demonstrated the feasibility of proposed PPG probe for continuous beat-to-beat local PWV measurement from the carotid artery. Such a non-invasive local PWV measurement unit can be potentially used for continuous ambulatory BP measurements.