Abstract
SUMMARY: While developing a standard mouse test for anti‐tuberculosis activity using intracerebral infection and a subjective criterion for assessing activity based on visual estimates of the extent of the lung lesions, young mice were found to be less resistant than older mice but male and female mice of similar ages and weights were equally susceptible. The bovine Ravenel and the human H418 strains of M. tuberculosis were selected as being more virulent and reliable than the H37Rv strain. Kirchner's medium was chosen out of three media equally good for yielding virulent cultures from which to grow cultures for inoculation. The ability of the standard mouse test devised, notwithstanding the use of a subjective criterion for assessment, to reveal activity in drugs whose effectiveness has been revealed by other methods, was demonstrated. A brief description is given of the disease produced in mice following intracerebral inoculation.
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