Abstract
AbstractThis unit provides three basic experimental protocols for transplantation into the adult, neonatal, and embryonic rat or mouse brain. These approaches differ not only with respect to their technical peculiarities but also in the spectrum of biological questions they can address. Also included are procedures for the construction of a simple injection device used in delivery of the cell suspension to be transplanted into the embryonic brain; preparation of single‐cell suspensions, which are the preferred form of donor material for transplantations; and two procedures, technically similar to the transplantation procedures, for modeling neurodegenerative disease in rodents: 6‐hydroxydopamine (6‐OHDA) lesioning as a model of Parkinson's disease and ibotenic acid lesioning as a model for Huntington's disease.
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