Abstract
Advancements in optical nanosensor development have enabled the design of sensors using syntheticmolecular recognition elements through a recently developed method called Corona Phase MolecularRecognition (CoPhMoRe). The synthetic sensors resulting from these design principles are highly selective for specific analytes, and demonstrate remarkable stability for use under a variety of conditions. An essential element of nanosensor development hinges on the ability to understand the interface between nanoparticles and the associated corona phase surrounding the nanosensor, an environment outside of the range of traditional characterization tools, such as NMR. This review discusses the need for new strategies and instrumentation to study the nanoparticle corona, operating in both in vitro and in vivo environments. Approaches to instrumentation must have the capacity to concurrently monitor nanosensor operation and the molecular changes in the corona phase. A detailed overview of new tools for the understanding of CoPhMoRe mechanisms is provided for future applications.
Highlights
In recent years, the use of nanomaterials for sensing applications has undergone rapid growth, in particular the development of high-sensitivity and high-specificity sensors for processes occurring at the molecular scale [1]
The engineering of novel molecular recognition entities on carbon nanotube surfaces has recently enabled the optical detection of analytes using an approach called Corona Phase Molecular Recognition (CoPhMoRe)
Recent work has succeeded in developing a synthesis platform for the design synthetic sensors, based on the principle of single-wall carbon nanotubes (SWCNT) CoPhMoRe
Summary
The use of nanomaterials for sensing applications has undergone rapid growth, in particular the development of high-sensitivity and high-specificity sensors for processes occurring at the molecular scale [1]. The engineering of novel molecular recognition entities on carbon nanotube surfaces has recently enabled the optical detection of analytes using an approach called Corona Phase Molecular Recognition (CoPhMoRe) This powerful technique benefits from the rational design of SWCNT-based sensors that produce high-specificity optical signals. Together with an emergent development in laser technology, this novel instrument has the capacity to study both nanoparticles and individual polymers simultaneously with spatial and temporal resolution that is appropriate for nanoscale interactions of the corona phase around SWCNT that impart sensing capabilities to nanosensors. Microscopy tools such as this are crucial for the development of sensors for use in vitro and in vivo
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