Abstract
Earlier studies have shown marked species specific differences of the effects of thyroid hormones on the basal metabolic rate (BMR) and on the induction of enzyme biosynthesis (1, 2). In order to produce experimental thyrotoxicosis closely resembling the pathophysiological conditions of human thyrotoxicosis, T4 plus T3 were applicated in a ratio of 3:1 (w/w), given for a period as long as 30 days and finally used in dosages ranging from very low to high.
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