Abstract
SummaryHetrazan had a spectacular and immediate effect against the microfilariae of Onchocerca volvulus but since it did not destroy the adult worms the disappearance of microfilariae was only temporary. Intravenous suramin, on the other hand, caused a more gradual disappearance of the microfilariae but since it also killed the adult worms, this disappearance was permanent in about 90 per cent of cases. Simultaneous treatment with intravenous suramin and oral Hetrazan combined the rapid action of Hetrazan with the permanent effect of suramin. Considering the added inconvenience of the additional treatment, it was not, however, thought to be superior to treatment with intravenous suramin alone. Oral administration of suramin was relatively ineffective.Specific recommendations for the treatment of onchocerciasis with intravenous suramin (Naphuride Sodium, Winthrop-Stearns) are given.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The American Journal of Tropical Medicine and Hygiene
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
