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Abstract
The authors in the process of experiment developed a model of generation of local chronic inflammatory processes in the nasal cavity. It has been established that the chronic hyperplastic inflammation of the nasal cavity mucous membrane simulated in the experiment, manifests itself in the changes of behavioral responses, the reduced body weight gain, high deep body temperature, development of tolerance for repeated local injection of infectious-allergic irritants, which confirms the clinical data on the interrelation between the local and systemic immune response in chronic hyperplastic rhinosinusitis and determines the search for diagnostic characteristics of the disease.
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