Abstract
The study of bacterial pathogeny represents a very important issue for the forensic specialists, clinicians, managers and healthcare policymakers. The purpose of this experimental research is to study the virulence of some infectious microbial agents (Pseudomonas Aeruginosa, Staphylococcus Aureus, Escherichia Coli, Proteus Mirabilis, Erysipelothrix Rhusiopathiae), some of them frequently involved in violent deaths presenting septic states, by inoculating them in white mice Mus Musculus (MMs), in the presence of competing factors of death, reproducing this way a model of human violent death consecutive of septic complications that occur in the evolution of some traumas.The results of the study show that the survival period of the MMs depends on the microbial agent of the inoculated strain, the dilution of the culture suspension, the presence of associated lesions, age. In decreasing order, according to the value of LD50, the most virulent strains are Erysipelothrix Rhusiopathiae, Escherichia Coli, Proteus Mirabilis, followed by Staphylococcus Aureus and Pseudomonas Aeruginosa. The lethality index increases proportionally with the virulence of the etiologic agent and the presence of the associated lesions, confirming once again the similarity with�physiopathological mechanisms that exist in human pathology.
Highlights
The study of bacterial pathogeny represents a very important issue for the forensic specialists, clinicians, managers and healthcare policymakers. The purpose of this experimental research is to study the virulence of some infectious microbial agents (Pseudomonas Aeruginosa, Staphylococcus Aureus, Escherichia Coli, Proteus Mirabilis, Erysipelothrix Rhusiopathiae), some of them frequently involved in violent deaths presenting septic states, by inoculating them in white mice Mus Musculus (MMs), in the presence of competing factors of death, reproducing this way a model of human violent death consecutive of septic complications that occur in the evolution of some traumas.The results of the study show that the survival period of the MMs depends on the microbial agent of the inoculated strain, the dilution of the culture suspension, the presence of Er associated lesions, age
GivTeasbLlDe505dpepreesnednintsg on the selected MMs groups. the evolution of the deaths as a consequence of the inoculation of the pathogenic agent at the dilution absence of aosfscohcoiasetendLlDe5s0i,odnesp. ending on the presence or Concluding, the calculation of dilutions regarding each culture of inoculated pathogenic agent, revealed that the most virulent strains are in descending order Erysipelotrix Rhusiopathiae, E
LthDe50ssuhroviwvatlhpaetritohde duration of the of MMs depend on the infectious microbial agent, the inoculation pathway, the dilution of the culture suspension, associated lesions, age
Summary
The study was conducted in the Legal Medicine Bihor County Service and Faculty of Medicine and Pharmacy of Oradea, between February 2012 - June 2013. The study was performed by inoculating to MMs some pathogen agents as strains tested on microbial cultures (in liquid environment or suspension from the agar culture) and suspensions obtained directly from pathological human products. For this purpose, in the first phase of the study, the pathogen agents were identified in different biological samples harvested from cadaver, on the occasion of medico-legal autopsy, in the Legal Medicine Bihor County Service. During the autopsy biological samples were harvested (blood, tissue fragments) to effectuate the microbiological and histopathological exam
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