Abstract
Garlic oil which is the main active constituent of garlic has a wide range of pharmacological activities, and a broad antibacterial spectrum. It also has a strong anti-cancer activity, and can significantly inhibit a variety of tumors such as liver cancer, gastric cancer and colon cancer. The objective is to study the extraction process of garlic oil and its antibacterial effects. CO2 Supercritical extraction was used to investigate the optimal processing conditions for garlic oil extraction; filter paper test and suspension dilution test were applied to determine the bacteriostatic action of garlic oil. In the CO2 supercritical extraction experiment, factors influencing the yield of garlic oil were: extraction pressure > extraction temperature > extraction time in descending order. Range analysis showed that the optimal experimental conditions for CO2 supercritical extraction of garlic oil were extraction pressure of 15 Mpa, temperature of 40 °C, and duration of 1 h. Different concentrations of garlic oil could all inhibit the growth of Staphylococcus aureus, Escherichia coli and Bacillus subtilis, suggesting that garlic oil has an antibacterial effect. The optimal experimental conditions for CO2 supercritical extraction of garlic oil were: extraction pressure of 15 Mpa, temperature of 40 °C, and duration of 1 h; garlic oil has an antibacterial effect.
Highlights
Garlic oil, whose chemical name is diallyl trisulfide, is the main active constituent of garlic
As can be seen from the experimental results, in the CO2 supercritical extraction test, that the factors influencing the yield of garlic oil were: B>A>C, that is, the degrees of influence to the experimental results were: extraction pressure > extraction temperature > extraction time in descending order
Range analysis showed that the optimal experimental conditions for CO2 supercritical extraction of garlic oil were B2A2C1, which means that the adoption of extraction pressure of 15 Mpa, temperature of 40°C, and duration of 1 h can maximize the extraction yield of garlic oil
Summary
Garlic oil, whose chemical name is diallyl trisulfide, is the main active constituent of garlic. Garlic oil has a wide range of pharmacological activities, and a broad antibacterial spectrum (Yang et al, 2008; He et al, 2008) It has a strong anti-cancer activity, and can significantly inhibit a variety of tumors such as liver cancer, gastric cancer and colon cancer (Hassan, 2004; Sundaram et al, 1996; Oltvai et al, 1993; Markos et al, 2008). Garlic oil which is the main active constituent of garlic has a wide range of pharmacological activities, and a broad antibacterial spectrum It has a strong anti-cancer activity, and can significantly inhibit a variety of tumors such as liver cancer, gastric cancer and colon cancer. Conclusion: The optimal experimental conditions for CO2 supercritical extraction of garlic oil were: extraction pressure of 15 Mpa, temperature of 40 °C, and duration of 1 h; garlic oil has an antibacterial effect
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