Abstract
Objective: To observe neuronal toxical effect of Levodopa and investigate whether using Levodopa together with EGb is an ideal, workable method to treat Parkinson disease. Methods: In this study, the rat models of Parkinson disease (PD) were made by injecting stereotaxically 6-OHDA to right side of the mesencephic ventral tegmental area (VTA) and substantia nigra pars compacta (SNc). We used rotational behaviour, TUNEL, immunocytochemical, Nissl’s body staining methods to observe the difference between Levodopa (50mg/kg/d×3d, ×5d, ×7d, L-dopa group) and the combination use of Levodopa and EGb (100 mg/kg/d, E-D group). Results: The numbers of apoptosis and rotation, bFGF protein expression in the L-dopa group surpassed those in the E-D group (P<0.05). The number of Nissl cells in the L-dopa group was fewer than the E-D group. Conclusion: Levodopa has neurological toxical effect. EGb may decrease the toxicity of levodopa. The combination use of Ginkgo biloba extract (EGb) and Levodopa is a workable method to treat Parkinson disease and is better than using Levodopa alone.
Highlights
MethodsThe rat models of Parkinson disease (PD) were made by injecting stereotaxically 6-OHDA to right side of the mesencephic ventral tegmental area (VTA) and substantia nigra pars compacta (SNc)
The background of Parkinson disease is degeneration of neuronal degeneration and death of compact part in substantial nigra of mesencephalon, and decreasing release of dopamine in striatum
It has not be reported that treating Parkinson disease using levodopa combining with Ginkgo biloba extract
Summary
The rat models of Parkinson disease (PD) were made by injecting stereotaxically 6-OHDA to right side of the mesencephic ventral tegmental area (VTA) and substantia nigra pars compacta (SNc). TUNEL, immunocytochemical, Nissl’s body staining methods to observe the difference between Levodopa (50mg/kg/d×3d, ×5d, ×7d, L-dopa group) and the combination use of Levodopa and EGb (100 mg/kg/d, E-D group)
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