Abstract
Objective To explore the role of electron beam in preventing tendon adhesion. Methods Based on the postoperative observation durations of 2, 4 and 8 weeks respectively, 30 healthy chickens were randomly divided into 3 groups with 10 each. The left foot was assigned as the experimental side, while the right foot as the control side. Flexor digitorum profundus tendons at zone Ⅱ in the 2nd , 3rd and 4th toes of both feet were transected and repaired with figure-of-eight suture. The chickens were raised cage free without immobilization after the surgery. Within 24 hours after the surgery electron beam (total 15 Gy) was applied to radiate the left leg. The right leg was left untreated. Gross observation, biomechanical tests and histological examination of the repaired tendons were carried out at 2, 4 and 8 weeks postoperatively. Results Tendons from the radiated side were significantly better in terms of adhesion, joint flexion angle, tendon excursion and tissue histology ( P ＜ 0.01 ). However the difference of the tensile strength was not significant between the experimental side and control side ( P ＞ 0.05). Conclusion Electron beam radiation following tendon repair can inhibit collagen proliferation and thus effectively prevent tendon adhesion. This provides an experimental model for the clinical application of electron beam. Key words: Tendons; Radiation; Chickens; Electron beam
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