Abstract
Objective To establish an animal model of SM in rabbits and research it's pathogenesis.Methods 16 rabbits were randomly divided into experimental group and control group,all animals were perfomed microsurgery via suboccipital midline approach.The core of pencil (diameter 0.5 mm,length 6 mm) was planted into spinal central canal via its opening in experimental group.MRI were carried out preoperation and 2,4,6,8 weeks after operation.All rabbits were executed after 8 weeks and spinal cord histological examinations were perfomed.Results The diameter of cervical spinal central canal were (0.505±0.046) mm in experimental group and (0.304 ±0.045) mm in control group,which have significance difference (t =8.787,P ＜ 0.05).The MRIT2 weighted sagittal films showed the linear high signal shadow at middle of cervical spinal cord 2 ～4 weeks after operation in experimental group and the linear high signal shadow became wider and longer in 6 ～ 8 weeks.Conclusion The SM model in rabbits were established successfully via mechanical obstruction of the opening of spinal central canal.The pathogenesis of SM pitients may be obstruction of the opening of spinal central canal caused by defferent kinds of elements. Key words: Syringomyelia; Chiari malformation; Central canal of spinal cord ; Animal model; Pathogenesis
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