Experimental study on influence of chronic stress on skin wound healing and skin graft survival time in mice

Abstract

Objective To investigate the influence of chronic stress on skin wound healing and skin graft survival time in mice. Methods In the study on skin wound healing,a full-thickness dermal wound on the hack of the female C57 BL/6J mice was made, then the mice were randomly divided into simple wound group and wound plus chronic stress group. The chronic stress was given in the latter group. The wound healing conditions of two groups were observed. Meanwhile, the female C57BL/6J mice were grafted with skin donated from the female BALB/C mice,and randomly divided into,the simple skin graft group and the skin graft plus chronic stress group. The chronic stress was given in the latter group. The skin graft survival time of two groups were observed. Re-sults Compared with simple wound group, the healing speed of the wound plus chronic stress group was notably lower, and the difference was significant (P 0.05). Conclusion Chronic stress may delay wound healing. But there is no certain conclusion that whether chronic stress impact on skin graft survival time. We need further investigation. Key words: Stress; Wound healing; Skin transplantation