Abstract
Objective: To explore the protective effect ofCordyceps sinensis (CS) on nephrotoxicity of cyclosporine A (CsA) and its mechanism.Methods: The renal function of isolated perfused rats was observed before and after three months treatment by CS.Results: CS could improve the renal function, increase the volume of urine, Na+ and K+ excretion and inulin clearance rate, and reduce the resistance of renal perfusion. It was found that the activities of urinary N-acetyl-β-glucosaminidase (NAG), γ-glutamyl transferase (γ-GT) and lactate dehydrogenase (LDH) were lower in the CS treatment group than those in the control group.Conclusion: CS could protect the kidney from damage against nephrotoxicity of CsA and improve the abnormality of renal hemodynamics.
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