EXPERIMENTAL STUDY ON DIABETES IN UROLOGY

Abstract

The biological, biochemical and histo-pathological studies were performed on the hypophysealadrenal system, testes and the other male accessory sex organs of the experimental diabetic rabbits. Seventy alloxan diabetic rabbits, in total, were obtained by the injection of alloxan monohydrate for the period of 1 to 25 weeks.The summarized results were as follows;1) The average weight of the adrenals was significantly increased by the administration of alloxan, but, on the contrary, the mean weight of the testes was decreased.2) The pituitary gonadotropic potency was considerably decreased. Another interesting fact was that the ratio of F. S. H. (follicle stimulating hormone) and L. H. (luteinizing hormone=I. C. S. H.; interstitial cell stimulating hormone) concentration was changed beyond the physiological limits.3) The cholesterol content in adrenal glands were increased during the initial 5 weeks after the alloxan administration, and then it showed a steady decline for long time.4) The adrenal ascorbic acid content was varied parallel with the change in the weight of the adrenals and testes.5) The testicular damage was the most prominent in seminal-tubules. Spermatozoa were, however, recognized in seminal-tubules more frequently than expected.6) No remarkable changes were observed in the seminal tubules, seminal vesicles, and prostate, while slight edema of the interstitial tissue were recognized.