Abstract
Objective To investigate the protective effect of calcium antagonists on kidneys stored in HC-A solution in the model of rabbit.Methods The isolated kidneys from rabbits were perfused w ith and then stored in HC-A solution at 4 ℃ for 24 h. HC-A solution contain ing verapamil (VP, a calcium antagonist) was added in some cas es. The contents of mitochondrial calcium and renal tissue's ATP were measured i n each group. Results The contents of mitochondrial calcium was remarkab ly higher and ATP was significantly lower in kidneys stored in HC-A solution at 4 ℃ for 24 h than in the normal control. If the HC-A solution containing VP was added, the changes mentioned above could be significantly hindered. Conclusion Calcium antagonists is beneficial to isolated kidney during its preservation in HC-A solution.
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