Abstract
Background: Scorpion sting is a frequent event in tropical and subtropical countries. The objective of this study is to evaluate Efficacy of Paravatadi Agada on Indian Red Scorpion Venom (Mesobuthus Tamulus). Materials and Methods: PA was prepared as per textual reference. Water soluble extract of PA was obtained using Soxhlet apparatus. Swiss albino mice of 20-30gm were used. Lypholised venom sample of Mesobuthus tamales and Lyophilized monovalent enzymerefined immunoglobuline anti scorpion venom serum (ASV) was used. Using lethal dose of scorpion venom (25.12 μg/g), venom neutralising property of PA extract (300mg/kg), ASV(1mg) intra-peritoneally and PA(31mg/mice) orally. The parameter used were Mean survival time, protection fold and percentage survival of animals over the period of 24 hrs. Histopathological examinations of all mice were done. Result: Maximum protection fold is seen in ASV treated group which is 10.03 with 83.33 % survival but water soluble extract of PA also showed some protective effect against scorpion venom 7.68 with 50 % survival rate. Histopathological examination showed that PA extract, ASV and PA treated group showed less effect of scorpion venom on Heart, Liver and Kidney compared to control group in which sever histopathological manifestations are detected. Conclusion : The protection fold and survival percentage of extract of PA was better than Powder form of PA but less than ASV but enough significant in view of availability, safety, ease in method of preparation and cost effectiveness compared to ASV.
Highlights
Scorpion sting is a frequent event in tropical and subtropical countries [1]
In India severe scorpion sting due to Mesobuthus tamales species of scorpion is mainly found in Kokan region [4]
Higher incidence of scorpion sting occurred during hot months attributed to increase in agricultural activity[5,6]
Summary
Scorpion sting is a frequent event in tropical and subtropical countries [1]. It is estimated that in India the annual number of scorpion stings cases exceeds 1.23 million, of which over 32,250 may be fatal. Using lethal dose of scorpion venom (25.12 μg/g), venom neutralising property of PA extract (300mg/kg), ASV(1mg) intraperitoneally and PA(31mg/mice) orally. Result: Maximum protection fold is seen in ASV treated group which is 10.03 with 83.33 % survival but water soluble extract of PA showed some protective effect against scorpion venom 7.68 with 50 % survival rate. Histopathological examination showed that PA extract, ASV and PA treated group showed less effect of scorpion venom on Heart, Liver and Kidney compared to control group in which sever histopathological manifestations are detected. Conclusion : The protection fold and survival percentage of extract of PA was better than Powder form of PA but less than ASV but enough significant in view of availability, safety, ease in method of preparation and cost effectiveness compared to ASV
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