Experimental study of the relationship between the content of stromal cell-derived factor-1 in different period of myocardial infarction and left ventricular function

Abstract

Objective To investigate the relationship between the content of stromal cell-derived factor-1(SDF-1) in myocardium in different period of myocardial infarction and left ventricular function. Methods Twenty-three Chinese miniature pigs were randomly divided into the experimental group and the control group. The swines in experimental group were prepared as acute myocardial infarction model by ligating anterior descending coronary artery and were randomly divided into 6 subgroups according to the different time points after infarction. The left ventricular end-diastolic diameter (LVDd), left ventricular ejection fraction (LVEF) and left ventricular fraction shortening (LVFS) were measured respectively. Global circumferential strain (GCS) and global radial strain (GRS) of left ventricle were measured. The content of SDF - 1 were also measured by real-time quantitative PCR. Results Compared with the control group, SDF-1 levels were significantly elevated, and LVEF, LVFS, GCS and GRS were reduced. However, LVDd were significantly increased. The content of SDF-1 and GCS has a negative correlation (r=-0.580, P=0.000). Conclusions The content of SDF - l in myocardial tissue have a certain relationship with GCS of left ventricular myocardium. Key words: Echocardiography; Myocardial infarction; Ventricular function, left; Chemokine CXCL12; Speckle tracking imaging