Abstract
Topicality. The combined application of nonsteroidal anti-inflammatory drugs (NSAIDs) and low-intensity infrared laser radiation (LIIRLR) for treatment of osteoarthrosis has remained an actual task. Aim to study the NSAIDs usage under LIIRLR application in experiments in rats.Materials and Methods. The time for LIIRLR application (15 min after drug administration) was chosen according to our previous studies on diclofenac sodium (DNa) pharmacokinetics in rats blood plasma. To study the NSAIDs application at the influence of LIIRLR, white beedless male rats (n=15) of 250-300 g were used in the experiments. The animals were divided into 3 groups. Rats of group the 1were received purified water (per os) and exposed to LIIRLR. Rats of group the 2 were received DNa at a dose of ED50 (per os, 8 mg/kg). Rats of group the 3 were influenced of LIIRLR and in 15 min received DNa (per os, 8 mg/kg). For DNa extraction from rat plasma samples, the method of solid-phase extraction was used. Concentration of DNa was determined by method of high-performance liquid chromatography (HPLC).Results. It was established that at the combined use LIIRLR and DNa the drug concentration in the rats blood serum was 1.7 fold higher in comparison to DNa application alone.Conclusions. It is proved, that the method of combine application of LIIRLRand NSAIDs (in 15 min) was more effective than the use of NSAIDs alone.
Highlights
Diseases of musculoskeletal system (MSS) and connective tissue are widespread in many countries of the world; they lead to decreased working capacity, worsening of the quality of life, social disadaptation, and, in the consequence, disability
Substance of Diclofenac sodium (DNa) manufactured by Borshchahivskiy Chemical-Pharmaceutical Plant (BCPP), Ukraine was used for the study
Animals used in the experiment: white beedless male rats of the population of experimental biological clinics of the State Enterprise “Sytenko Institute of Spine and Joint Pathology of the National Academy of Medical Sciences of Ukraine”
Summary
Diseases of musculoskeletal system (MSS) and connective tissue are widespread in many countries of the world; they lead to decreased working capacity, worsening of the quality of life, social disadaptation, and, in the consequence, disability. Osteoarthrosis (OA) is leading as for incidence among this category of diseases. At least 20 % of world population suffer from it. That is why its treatment is a medical and social problem that is urgent all over the world [1, 2]. There are various drugs and methods of treatment for MSS and connective tissue diseases. Nonsteroidal antiinflammatory drugs (NSAIDs) constitute one of the central positions in therapy of these diseases and are most widely used in modern medicine, clinical practice, and pharmacy [2, 4]
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