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Abstract
BackgroundOur aim was to explore the de-addiction properties of Delphinium denudatum Wall. in morphine dependent rats.MethodsCharles Foster male albino rats were made morphine dependent by injecting morphine sulphate in increasing doses twice a day for 7 days. The spontaneous withdrawal signs observed 12 h after the last dose were quantified by the 'counted' and 'checked' signs. The drug (alcoholic extract of Delphinium denudatum) was administered p.o. in different regimen: a) single dose (700 mg/kg) 10 h before the first dose of morphine, b) single dose (700 mg/kg) 10 h after the last dose of morphine, c) multiple doses (350 mg/kg) along with morphine twice a day for 7 days.ResultAdministration of Delphinium denudatum extract caused significant reduction in the frequency of counted signs as well as the presence of checked signs of morphine withdrawal. The maximum reduction was observed in regimen 'b' followed by regimen 'c' and 'a'.ConclusionDelphinium denudatum Wall. significantly reduces the aggregate scores for all parameters in morphine withdrawal syndrome by central action and thus may prove to be an alternative remedy in morphine de-addiction.
Highlights
Our aim was to explore the de-addiction properties of Delphinium denudatum Wall. in morphine dependent rats
In group 4, in which alcoholic extract of D. d. in dose of 350 mg/kg was given alongwith morphine showed reduction in the withdrawal signs of morphine dependence as observed by lower values of checked and counted signs when compared to morphine treated group 3
Animals of group 5, which were administered with single dose of alcoholic extract of D. d. (700 mg/kg) 10 h after the last dose of morphine, i.e. 2 h before the time of observation, showed marked reduction in the appearance of withdrawal signs of morphine dependence
Summary
Our aim was to explore the de-addiction properties of Delphinium denudatum Wall. in morphine dependent rats. Our aim was to explore the de-addiction properties of Delphinium denudatum Wall. (Jadwar, family; Ranunculaceae) is found on the outer ranges of western Himalayas from Kashmir to Kumaon. It is one of the most important drugs used in the indigenous system of medicine in India, especially in Unani Medicine. A number of studies have been done on its phytochemical and pharmacological properties [6,7,8]. Its de-addiction property in moderately induced morphine dependence was first studied and reported by us [9]. The study was further extended to explore the suppression of withdrawal signs by D. denudatum in rats during severely induced morphine dependence
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